Version 5.4
Homo sapiens Gene: SCG2
Summary
InnateDB Gene IDBG-82257.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCG2
Gene Name secretogranin II
Synonyms CHGC; EM66; SgII; SN
Species Homo sapiens
Ensembl Gene ENSG00000171951
Encoded Proteins
IDBP-82259
secretogranin II
IDBP-389130
secretogranin II
IDBP-389131
secretogranin II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:223596940-223602503
Strand Reverse strand
Band q36.1
Transcripts
ENST00000305409 ENSP00000304133
ENST00000421386 ENSP00000394702
ENST00000433889 ENSP00000415468
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0042056 chemoattractant activity
Biological Process
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006928 cellular component movement
GO:0006954 inflammatory response
GO:0009306 protein secretion
GO:0035556 intracellular signal transduction
GO:0043542 endothelial cell migration
GO:0048245 eosinophil chemotaxis
GO:0050918 positive chemotaxis
GO:0050930 induction of positive chemotaxis
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0030141 secretory granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050711
View Gene Order
ENSBTAG00000021588
Not yet available
Cross-References
SwissProt P13521
TrEMBL C9JDT0 C9JQI2
UniProt Splice Variant
Entrez Gene 7857
UniGene Hs.516726 Hs.707360
RefSeq NM_003469
HUGO HGNC:10575
OMIM 118930
CCDS CCDS2457
HPRD
IMGT
EMBL AC012512 AK312452 BC022509 CH471063 M25756
GenPept AAA36607 AAH22509 AAY24243 BAG35359 EAW70811
RNA Seq Atlas 7857

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca