Version 5.4
Homo sapiens Gene: EXOC6
Summary
InnateDB Gene IDBG-82578.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EXOC6
Gene Name exocyst complex component 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138190
Encoded Proteins
IDBP-82580
exocyst complex component 6
IDBP-82584
exocyst complex component 6
IDBP-82586
exocyst complex component 6
IDBP-382520
exocyst complex component 6
IDBP-382531
exocyst complex component 6
IDBP-595548
exocyst complex component 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the SEC15 family. It is highly similar to the protein encoded by Saccharomyces cerevisiae SEC15 gene. This protein is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:92834713-93059493
Strand Forward strand
Band q23.33
Transcripts
ENST00000371552 ENSP00000360607
ENST00000260762 ENSP00000260762
ENST00000371543 ENSP00000360598
ENST00000443748 ENSP00000396206
ENST00000458552 ENSP00000398982
ENST00000497262
ENST00000495132 ENSP00000435649
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006904 vesicle docking involved in exocytosis
GO:0015031 protein transport
GO:0030218 erythrocyte differentiation
GO:0044267 cellular protein metabolic process
GO:0061024 membrane organization
Cellular Component
GO:0000145 exocyst
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053799
View Gene Order
ENSBTAG00000021116
Not yet available
Pathways
NETPATH
REACTOME
REACT_15550
Insulin processing pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
arf6_traffickingpathway
Arf6 trafficking events
insulin_pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.609160 Hs.655657
RefSeq NM_001013848 NM_019053 XM_005269912 XM_005269915 XM_006717898
HUGO
OMIM
CCDS CCDS31247 CCDS7424
HPRD 10216
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca