Version 5.4
Homo sapiens Gene: VAPB
Summary
InnateDB Gene IDBG-82596.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VAPB
Gene Name VAMP (vesicle-associated membrane protein)-associated protein B and C
Synonyms ALS8; VAMP-B; VAP-B
Species Homo sapiens
Ensembl Gene ENSG00000124164
Encoded Proteins
IDBP-238810
VAMP (vesicle-associated membrane protein)-associated protein B and C
IDBP-479641
VAMP (vesicle-associated membrane protein)-associated protein B and C
IDBP-485473
VAMP (vesicle-associated membrane protein)-associated protein B and C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:58389122-58451101
Strand Forward strand
Band q13.32
Transcripts
ENST00000265619
ENST00000395802 ENSP00000379147
ENST00000475243 ENSP00000417175
ENST00000520497 ENSP00000430426
ENST00000463370
ENST00000476395
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
Experimentally validated
Total 71 [view]
Protein-Protein 70 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0048487 beta-tubulin binding
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006874 cellular calcium ion homeostasis
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0008219 cell death
GO:0019048 modulation by virus of host morphology or physiology
GO:0030148 sphingolipid biosynthetic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044281 small molecule metabolic process
GO:0045070 positive regulation of viral genome replication
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054455
View Gene Order
ENSBTAG00000017424
Not yet available
Pathways
NETPATH
REACTOME
REACT_115810
Sphingolipid de novo biosynthesis pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.182625 Hs.601751 Hs.732472
RefSeq NM_001195677 NM_004738 XM_006723888
HUGO
OMIM
CCDS CCDS33498 CCDS56198
HPRD 09300
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca