Homo sapiens Gene: CYP26C1
Summary
InnateDB Gene IDBG-82642.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP26C1
Gene Name cytochrome P450, family 26, subfamily C, polypeptide 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000187553
Encoded Proteins
cytochrome P450, family 26, subfamily C, polypeptide 1
cytochrome P450, family 26, subfamily C, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome 10q23.33. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:93060808-93069536
Strand Forward strand
Band q23.33
Transcripts
ENST00000285949 ENSP00000285949
ENST00000624358 ENSP00000485098
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001972 retinoic acid binding
GO:0005506 iron ion binding
GO:0008401 retinoic acid 4-hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
Biological Process
GO:0006766 vitamin metabolic process
GO:0006805 xenobiotic metabolic process
GO:0007417 central nervous system development
GO:0009952 anterior/posterior pattern specification
GO:0014032 neural crest cell development
GO:0034653 retinoic acid catabolic process
GO:0044281 small molecule metabolic process
GO:0048284 organelle fusion
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cytochrome P450 - arranged by substrate type pathway
Metabolism pathway
Vitamins pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Retinol metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 340665
UniGene
RefSeq NM_183374
HUGO HGNC:20577
OMIM 608428
CCDS CCDS7425
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 340665