Version 5.4
Homo sapiens Gene: O3FAR1
Summary
InnateDB Gene IDBG-82780.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol O3FAR1
Gene Name omega-3 fatty acid receptor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186188
Encoded Proteins
IDBP-82782
omega-3 fatty acid receptor 1
IDBP-82784
omega-3 fatty acid receptor 1
IDBP-811454
free fatty acid receptor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:93566665-93604480
Strand Forward strand
Band q23.33
Transcripts
ENST00000371483 ENSP00000360538
ENST00000371481 ENSP00000360536
ENST00000604414 ENSP00000474477
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005504 fatty acid binding
GO:0005515 protein binding
GO:0008527 taste receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0010827 regulation of glucose transport
GO:0043066 negative regulation of apoptotic process
GO:0046879 hormone secretion
GO:0050710 negative regulation of cytokine secretion
GO:0050728 negative regulation of inflammatory response
GO:0050912 detection of chemical stimulus involved in sensory perception of taste
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030139 endocytic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054200
View Gene Order
ENSBTAG00000000437
Not yet available
Pathways
NETPATH
REACTOME
REACT_21268
Free fatty acid receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_24019
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_23974
Incretin synthesis, secretion, and inactivation pathway
REACT_17015
Metabolism of proteins pathway
REACT_21340
GPCR ligand binding pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001195755 NM_181745
HUGO
OMIM
CCDS CCDS31248 CCDS55720
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca