InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AMOT

Summary

InnateDB Gene

IDBG-82880.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AMOT

Gene Name

angiomotin

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000126016

Encoded Proteins

IDBP-82882

angiomotin

IDBP-82884

angiomotin

IDBP-82886

angiomotin

IDBP-82888

angiomotin

IDBP-475393

angiomotin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:112774503-112840815

Strand

Reverse strand

Band

q23

Transcripts

ENST00000304758	ENSP00000305557
ENST00000371962	ENSP00000361030
ENST00000371959	ENSP00000361027
ENST00000371958	ENSP00000361026
ENST00000524145	ENSP00000429013
ENST00000462114

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.

Experimentally validated
Total	95 [view]
Protein-Protein	94 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0043532	angiostatin binding

Biological Process

GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0001702	gastrulation with mouth forming second
GO:0003365	establishment of cell polarity involved in ameboidal cell migration
GO:0006935	chemotaxis
GO:0007043	cell-cell junction assembly
GO:0016525	negative regulation of angiogenesis
GO:0030036	actin cytoskeleton organization
GO:0030334	regulation of cell migration
GO:0034260	negative regulation of GTPase activity
GO:0034613	cellular protein localization
GO:0035329	hippo signaling
GO:0040019	positive regulation of embryonic development
GO:0042074	cell migration involved in gastrulation
GO:0043116	negative regulation of vascular permeability
GO:0043534	blood vessel endothelial cell migration
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0045793	positive regulation of cell size
GO:0048514	blood vessel morphogenesis
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051496	positive regulation of stress fiber assembly

Cellular Component

GO:0001725	stress fiber
GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005884	actin filament
GO:0005923	tight junction
GO:0008180	COP9 signalosome
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030027	lamellipodium
GO:0030139	endocytic vesicle
GO:0031410	cytoplasmic vesicle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000041688

View Gene Order

ENSBTAG00000016221

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.528051 Hs.601845 Hs.624439 Hs.738729

RefSeq

NM_001113490 NM_133265 XM_005262087 XM_005262088 XM_005262089 XM_005262090 XM_006724623

HUGO

OMIM

CCDS

CCDS14563 CCDS48154

HPRD

02327

IMGT

EMBL

GenPept

RNA Seq Atlas