Version 5.4
Homo sapiens Gene: PLS3
Summary
InnateDB Gene IDBG-83039.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLS3
Gene Name plastin 3
Synonyms BMND18; T-plastin
Species Homo sapiens
Ensembl Gene ENSG00000102024
Encoded Proteins
IDBP-83041
plastin 3
IDBP-83043
plastin 3
IDBP-379495
plastin 3
IDBP-473781
plastin 3
IDBP-475844
plastin 3
IDBP-809321
plastin 3
IDBP-476860
plastin 3
IDBP-602722
plastin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83%% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:115561174-115650861
Strand Forward strand
Band q23
Transcripts
ENST00000289290 ENSP00000289290
ENST00000355899 ENSP00000348163
ENST00000420625 ENSP00000398945
ENST00000489283 ENSP00000420458
ENST00000481823 ENSP00000419051
ENST00000473026 ENSP00000475900
ENST00000497870 ENSP00000417728
ENST00000466150
ENST00000539310 ENSP00000445339
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 27 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0060348 bone development
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016382
View Gene Order
ENSBTAG00000011613
Not yet available
Cross-References
SwissProt
TrEMBL B4DG31 B4DI60 F8W8D8
UniProt Splice Variant
Entrez Gene 5358
UniGene Hs.496622
RefSeq NM_001282337 NM_001136025 NM_001172335 NM_001282338 NM_005032
HUGO HGNC:9091
OMIM 300131
CCDS CCDS14568 CCDS65312
HPRD 02133
IMGT
EMBL AC003983 AC005000 AK294385 AK295429 AL589842
GenPept BAG57642 BAG58372
RNA Seq Atlas 5358

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca