Homo sapiens Gene: HTR2B
Summary
InnateDB Gene IDBG-83044.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTR2B
Gene Name 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
Synonyms 5-HT(2B); 5-HT2B;
Species Homo sapiens
Ensembl Gene ENSG00000135914
Encoded Proteins
5-hydroxytryptamine (serotonin) receptor 2B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:231108230-231125118
Strand Reverse strand
Band q37.1
Transcripts
ENST00000258400 ENSP00000258400
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001965 G-protein alpha-subunit binding
GO:0004930 G-protein coupled receptor activity
GO:0004993 serotonin receptor activity
GO:0005099 Ras GTPase activator activity
GO:0008144 drug binding
GO:0051378 serotonin binding
Biological Process
GO:0001755 neural crest cell migration
GO:0001819 positive regulation of cytokine production
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002031 G-protein coupled receptor internalization
GO:0003007 heart morphogenesis
GO:0003300 cardiac muscle hypertrophy
GO:0006182 cGMP biosynthetic process
GO:0006874 cellular calcium ion homeostasis
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007210 serotonin receptor signaling pathway
GO:0007507 heart development
GO:0007610 behavior
GO:0008284 positive regulation of cell proliferation
GO:0010507 negative regulation of autophagy
GO:0010513 positive regulation of phosphatidylinositol biosynthetic process
GO:0014033 neural crest cell differentiation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014827 intestine smooth muscle contraction
GO:0016310 phosphorylation
GO:0019722 calcium-mediated signaling
GO:0032320 positive regulation of Ras GTPase activity
GO:0042310 vasoconstriction
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 positive regulation of MAP kinase activity
GO:0048598 embryonic morphogenesis
GO:0050715 positive regulation of cytokine secretion
GO:0050795 regulation of behavior
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051781 positive regulation of cell division
GO:0060548 negative regulation of cell death
GO:0070371 ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070528 protein kinase C signaling
GO:0071502 cellular response to temperature stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0043005 neuron projection
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Serotonin receptors pathway
Amine ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
Gap junction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P41595
TrEMBL B3VRC5 B3VRD0 B3VRD5
UniProt Splice Variant
Entrez Gene 3357
UniGene Hs.421649
RefSeq NM_000867 XM_005246520
HUGO HGNC:5294
OMIM 601122
CCDS CCDS2483
HPRD 03077
IMGT
EMBL AC009407 AF156158 AF156159 AF156160 AK313741 AY136751 BC063123 CH471063 EU796439 EU796444 EU796449 X77307 Z36748
GenPept AAD39259 AAH63123 AAN01277 AAX93128 ACE96333 ACE96338 ACE96343 BAG36482 CAA54513 CAA85319 EAW70949
RNA Seq Atlas 3357