Version 5.4
Homo sapiens Gene: AGTR2
Summary
InnateDB Gene IDBG-83075.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGTR2
Gene Name angiotensin II receptor, type 2
Synonyms AT2; ATGR2; MRX88
Species Homo sapiens
Ensembl Gene ENSG00000180772
Encoded Proteins
IDBP-83077
angiotensin II receptor, type 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:116170722-116174972
Strand Forward strand
Band q23
Transcripts
ENST00000371906 ENSP00000360973
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004945 angiotensin type II receptor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0017046 peptide hormone binding
GO:0048019 receptor antagonist activity
Biological Process
GO:0001822 kidney development
GO:0001974 blood vessel remodeling
GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0002018 renin-angiotensin regulation of aldosterone production
GO:0002033 vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
GO:0002035 brain renin-angiotensin system
GO:0006883 cellular sodium ion homeostasis
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007263 nitric oxide mediated signal transduction
GO:0007420 brain development
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell proliferation
GO:0010243 response to organonitrogen compound
GO:0010459 negative regulation of heart rate
GO:0010700 negative regulation of norepinephrine secretion
GO:0021695 cerebellar cortex development
GO:0030308 negative regulation of cell growth
GO:0032304 negative regulation of icosanoid secretion
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0035556 intracellular signal transduction
GO:0035566 regulation of metanephros size
GO:0035640 exploration behavior
GO:0035815 positive regulation of renal sodium excretion
GO:0035932 aldosterone secretion
GO:0038166 angiotensin-activated signaling pathway
GO:0042416 dopamine biosynthetic process
GO:0042990 regulation of transcription factor import into nucleus
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045909 positive regulation of vasodilation
GO:0048147 negative regulation of fibroblast proliferation
GO:0050715 positive regulation of cytokine secretion
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway
GO:0060993 kidney morphogenesis
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0071549 cellular response to dexamethasone stimulus
GO:0072300 positive regulation of metanephric glomerulus development
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:1900116 extracellular negative regulation of signal transduction
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000068122
View Gene Order
ENSBTAG00000040386
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04614
Renin-angiotensin system pathway
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt P50052
TrEMBL Q6UVH2
UniProt Splice Variant
Entrez Gene 186
UniGene Hs.405348 Hs.601592
RefSeq NM_000686
HUGO HGNC:338
OMIM 300034
CCDS CCDS14569
HPRD
IMGT
EMBL AH013177 AK313927 AL732602 AY322542 AY324607 AY536522 BC095504 CH471234 CR541969 L34579 U10273 U15592 U16957 U20860 U27478 X87723
GenPept AAA50762 AAA61794 AAA67753 AAA84900 AAA85851 AAA98990 AAH95504 AAP72969 AAP84355 AAQ62073 AAS45437 BAG36648 CAA61022 CAG46767 CAI40984 EAW51502
RNA Seq Atlas 186

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca