Version 5.4
Homo sapiens Gene: NCL
Summary
InnateDB Gene IDBG-83089.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCL
Gene Name nucleolin
Synonyms C23
Species Homo sapiens
Ensembl Gene ENSG00000115053
Encoded Proteins
IDBP-83091
nucleolin
IDBP-83095
nucleolin
IDBP-389261
nucleolin
IDBP-389262
nucleolin
IDBP-389263
nucleolin
IDBP-389264
nucleolin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:231453531-231483641
Strand Reverse strand
Band q37.1
Transcripts
ENST00000322723 ENSP00000318195
ENST00000356936 ENSP00000349410
ENST00000454824 ENSP00000401620
ENST00000417652 ENSP00000392747
ENST00000453992 ENSP00000413775
ENST00000436894 ENSP00000401322
ENST00000461347
ENST00000466274
ENST00000494618
ENST00000484328
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 233 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 233 [view]
Protein-Protein 228 [view]
Protein-DNA 4 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005488 binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0042162 telomeric DNA binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001525 angiogenesis
GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005938 cell cortex
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026234
View Gene Order
ENSBTAG00000016174
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
INOH
PID NCI
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
myc_activpathway
Validated targets of C-MYC transcriptional activation
aurora_b_pathway
Aurora B signaling
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.253767 Hs.79110
RefSeq NM_005381
HUGO
OMIM
CCDS CCDS33397
HPRD 01245
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca