Homo sapiens Gene: PTMA
Summary
InnateDB Gene IDBG-83127.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTMA
Gene Name prothymosin, alpha
Synonyms TMSA;
Species Homo sapiens
Ensembl Gene ENSG00000187514
Encoded Proteins
prothymosin, alpha
prothymosin, alpha
prothymosin, alpha
prothymosin, alpha
prothymosin, alpha
prothymosin, alpha
prothymosin, alpha
prothymosin, alpha
prothymosin, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PTMA interaction with STAT3 is IFN-induced and results in the nuclear translocation of the complex.
PTMA inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon (IFN) induction by acting as a ligand for TLR4 and stimulating type I IFN production to potently suppress HIV-1 after entry into cells.
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:231706895-231713541
Strand Forward strand
Band q37.1
Transcripts
ENST00000341369 ENSP00000344547
ENST00000409321 ENSP00000386645
ENST00000409115 ENSP00000386819
ENST00000409683 ENSP00000386519
ENST00000410064 ENSP00000387102
ENST00000448874 ENSP00000400406
ENST00000412128 ENSP00000406903
ENST00000440384 ENSP00000392732
ENST00000466801
ENST00000481928
ENST00000468027
ENST00000467816
ENST00000612829 ENSP00000478904
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
Experimentally validated
Total 72 [view]
Protein-Protein 67 [view]
Protein-DNA 0
Protein-RNA 4 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt P06454
TrEMBL B8ZZA1 B8ZZQ6 B8ZZW7 F8WCE8 H7C031 Q53S24 Q7KZ52 Q7Z4R6
UniProt Splice Variant
Entrez Gene 728026
UniGene Hs.464163
RefSeq NM_001099285 NM_002823 XM_001126659 XM_003960458 XM_005275719 XM_005276418
HUGO HGNC:9623
OMIM 188390
CCDS CCDS42833 CCDS46541
HPRD
IMGT
EMBL AC073476 AF348514 AF452640 AK223605 AK314106 BC003510 BC034921 BC051265 BC066905 BC070480 BC071647 BC071879 BC098420 J04797 M14483 M14630 M14794 M26708 M67480 S56449
GenPept AAA60213 AAA61182 AAA61183 AAA61184 AAA63239 AAA63240 AAD13882 AAH03510 AAH34921 AAH51265 AAH66905 AAH70480 AAH71647 AAH71879 AAH98420 AAK30146 AAP97694 AAY24150 BAD97325 BAG36799
RNA Seq Atlas 100302285 100422872 100422885 100506248 5757 728026