|Homo sapiens Gene: PTMA|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||prothymosin, alpha|
|Useful resources||Stemformatics EHFPI ImmGen|
PTMA interaction with STAT3 is IFN-induced and results in the nuclear translocation of the complex.
PTMA inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon (IFN) induction by acting as a ligand for TLR4 and stimulating type I IFN production to potently suppress HIV-1 after entry into cells.
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|Genomic Location||Chromosome 2:231706895-231713541|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
|No orthologs found for this gene|
Validated targets of C-MYC transcriptional activation
|TrEMBL||B8ZZA1 B8ZZQ6 B8ZZW7 F8WCE8 H7C031 Q53S24 Q7KZ52 Q7Z4R6|
|UniProt Splice Variant|
|RefSeq||NM_001099285 NM_002823 XM_001126659 XM_003960458 XM_005275719 XM_005276418|
|EMBL||AC073476 AF348514 AF452640 AK223605 AK314106 BC003510 BC034921 BC051265 BC066905 BC070480 BC071647 BC071879 BC098420 J04797 M14483 M14630 M14794 M26708 M67480 S56449|
|GenPept||AAA60213 AAA61182 AAA61183 AAA61184 AAA63239 AAA63240 AAD13882 AAH03510 AAH34921 AAH51265 AAH66905 AAH70480 AAH71647 AAH71879 AAH98420 AAK30146 AAP97694 AAY24150 BAD97325 BAG36799|
|RNA Seq Atlas||100302285 100422872 100422885 100506248 5757 728026|