InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ALPP

Summary

InnateDB Gene

IDBG-83209.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALPP

Gene Name

alkaline phosphatase, placental

Synonyms

ALP; PALP; PLAP; PLAP-1

Species

Homo sapiens

Ensembl Gene

ENSG00000163283

Encoded Proteins

IDBP-246493

alkaline phosphatase, placental

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3\' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:232378534-232382889

Strand

Forward strand

Band

q37.1

Transcripts

ENST00000392027	ENSP00000375881
ENST00000474529
ENST00000485563

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004035	alkaline phosphatase activity
GO:0008270	zinc ion binding
GO:0016791	phosphatase activity

Biological Process

GO:0008152	metabolic process
GO:0016311	dephosphorylation

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0031225	anchored component of membrane

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

KEGG

hsa00790

Folate biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.284255

RefSeq

NM_001632 XM_005246439

HUGO

OMIM

CCDS

CCDS2490

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas