Homo sapiens Gene: TGM5
Summary
InnateDB Gene IDBG-8322.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGM5
Gene Name transglutaminase 5
Synonyms TGASE5; TGASEX; TGM6; TGMX; TGX;
Species Homo sapiens
Ensembl Gene ENSG00000104055
Encoded Proteins
transglutaminase 5
transglutaminase 5
transglutaminase 5
transglutaminase 5
transglutaminase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:43232595-43266857
Strand Reverse strand
Band q15.2
Transcripts
ENST00000220420 ENSP00000220420
ENST00000349114 ENSP00000220419
ENST00000396996
ENST00000563838
ENST00000610827 ENSP00000479732
ENST00000622115 ENSP00000479638
ENST00000611276 ENSP00000482542
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006464 cellular protein modification process
GO:0008544 epidermis development
GO:0018149 peptide cross-linking
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004245 NM_201631
HUGO
OMIM
CCDS CCDS32211 CCDS32212
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas