Homo sapiens Gene: TUBB1
Summary
InnateDB Gene IDBG-83326.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TUBB1
Gene Name tubulin, beta 1 class VI
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101162
Encoded Proteins
tubulin, beta 1 class VI
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:59019254-59026654
Strand Forward strand
Band q13.32
Transcripts
ENST00000217133 ENSP00000217133
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006457 protein folding
GO:0007017 microtubule-based process
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
GO:0051225 spindle assembly
GO:0051258 protein polymerization
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Formation of tubulin folding intermediates by CCT/TriC pathway
Protein folding pathway
Post-chaperonin tubulin folding pathway pathway
MHC class II antigen presentation pathway
Transmembrane transport of small molecules pathway
Kinesins pathway
Developmental Biology pathway
Signaling by Hedgehog pathway
Recruitment of NuMA to mitotic centrosomes pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Transport of connexons to the plasma membrane pathway
Axon guidance pathway
Signal Transduction pathway
Separation of Sister Chromatids pathway
Hedgehog 'off' state pathway
Gap junction trafficking pathway
Chaperonin-mediated protein folding pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
Recycling pathway of L1 pathway
Orphan transporters pathway
Metabolism of proteins pathway
Adaptive Immune System pathway
Immune System pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Gap junction assembly pathway
M Phase pathway
Mitotic Anaphase pathway
Centrosome maturation pathway
G2/M Transition pathway
Translocation of GLUT4 to the plasma membrane pathway
L1CAM interactions pathway
Factors involved in megakaryocyte development and platelet production pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane pathway
Resolution of Sister Chromatid Cohesion pathway
Gap junction trafficking and regulation pathway
Hemostasis pathway
Membrane Trafficking pathway
Mitotic Metaphase and Anaphase pathway
KEGG
Phagosome pathway
Gap junction pathway
Pathogenic Escherichia coli infection pathway
INOH
PID BIOCARTA
Stathmin and breast cancer resistance to antimicrotubule agents [Biocarta view]
PID NCI
Cross-References
SwissProt Q9H4B7
TrEMBL
UniProt Splice Variant
Entrez Gene 81027
UniGene Hs.303023 Hs.718571
RefSeq NM_030773
HUGO HGNC:16257
OMIM 612901
CCDS CCDS13475
HPRD
IMGT
EMBL AJ292757 AL109840 BC033679
GenPept AAH33679 CAC09371 CAC16605
RNA Seq Atlas 81027