Version 5.4
Homo sapiens Gene: IL13RA1
Summary
InnateDB Gene IDBG-83434.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL13RA1
Gene Name interleukin 13 receptor, alpha 1
Synonyms CD213A1; IL-13Ra; NR4
Species Homo sapiens
Ensembl Gene ENSG00000131724
Encoded Proteins
IDBP-83436
interleukin 13 receptor, alpha 1
IDBP-83438
interleukin 13 receptor, alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21097505
IL13RA1 is a receptor for IL13. Upon ligand engagement, IL13RA1 activates the transcription factor STAT6 to induce M2 expression profile in macrophages.
Entrez Gene
Summary The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:118727572-118794539
Strand Forward strand
Band q24
Transcripts
ENST00000371666 ENSP00000360730
ENST00000371642 ENSP00000360705
ENST00000481868
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 2 [view]
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
GO:0016515 interleukin-13 receptor activity
Biological Process
GO:0002639 positive regulation of immunoglobulin production
GO:0007166 cell surface receptor signaling pathway
GO:0019221 cytokine-mediated signaling pathway
GO:0030890 positive regulation of B cell proliferation
GO:0035772 interleukin-13-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0005898 interleukin-13 receptor complex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017057
View Gene Order
ENSBTAG00000019338
Not yet available
Pathways
NETPATH
NetPath_16
IL4 pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-13 signaling pathway
PID NCI
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.496646 Hs.599499
RefSeq NM_001560 XM_005262411
HUGO
OMIM
CCDS CCDS14573
HPRD 02125
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca