Version 5.4
Homo sapiens Gene: PACSIN1
Summary
InnateDB Gene IDBG-83573.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PACSIN1
Gene Name protein kinase C and casein kinase substrate in neurons 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124507
Encoded Proteins
IDBP-83575
protein kinase C and casein kinase substrate in neurons 1
IDBP-83577
protein kinase C and casein kinase substrate in neurons 1
IDBP-602330
protein kinase C and casein kinase substrate in neurons 1
IDBP-807034
protein kinase C and casein kinase substrate in neurons 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22488361
PACSIN1 regulates the TLR7/9-mediated type I interferon response in plasmacytoid dendritic cells.
InnateDB Annotation from Orthologs
Summary
PMID 22488361
[Mus musculus] Pacsin1 regulates the Tlr7/9-mediated type I interferon response in plasmacytoid dendritic cells.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 6:34466061-34535231
Strand Forward strand
Band p21.31
Transcripts
ENST00000244458 ENSP00000244458
ENST00000374043 ENSP00000363155
ENST00000493633
ENST00000486120
ENST00000487760
ENST00000538621 ENSP00000439639
ENST00000620693 ENSP00000484060
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0007015 actin filament organization
GO:0045087 innate immune response (InnateDB)
GO:0045806 negative regulation of endocytosis
GO:0048488 synaptic vesicle endocytosis
GO:0048666 neuron development
GO:0048812 neuron projection morphogenesis
GO:0072657 protein localization to membrane
GO:0090002 establishment of protein localization to plasma membrane
GO:0097320 membrane tubulation
GO:1900006 positive regulation of dendrite development
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030054 cell junction
GO:0030137 COPI-coated vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0032587 ruffle membrane
GO:0043679 axon terminus
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040276
View Gene Order
ENSBTAG00000016124
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.520087
RefSeq NM_001199583 NM_020804
HUGO
OMIM
CCDS CCDS4793
HPRD 05936
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca