Version 5.4
Homo sapiens Gene: DAB2IP
Summary
InnateDB Gene IDBG-83597.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAB2IP
Gene Name DAB2 interacting protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136848
Encoded Proteins
IDBP-83605
DAB2 interacting protein
IDBP-83607
DAB2 interacting protein
IDBP-83609
DAB2 interacting protein
IDBP-241785
DAB2 interacting protein
IDBP-295212
DAB2 interacting protein
IDBP-379530
DAB2 interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19948740
DAB2IP functions as ARF6-GTPase activating protein to negatively regulate phosphatidylinositol 4, 5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 signaling.
Entrez Gene
Summary DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:121567057-121785530
Strand Forward strand
Band q33.2
Transcripts
ENST00000373782 ENSP00000362887
ENST00000259371 ENSP00000259371
ENST00000309989 ENSP00000310827
ENST00000394340 ENSP00000377872
ENST00000408936 ENSP00000386183
ENST00000436835 ENSP00000409327
ENST00000489314
ENST00000465078
ENST00000487716
ENST00000459906
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005099 Ras GTPase activator activity
GO:0005123 death receptor binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0032403 protein complex binding
GO:0035591 signaling adaptor activity
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0051721 protein phosphatase 2A binding
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0071889 14-3-3 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000185 activation of MAPKKK activity
GO:0001525 angiogenesis
GO:0001933 negative regulation of protein phosphorylation
GO:0006927 transformed cell apoptotic process
GO:0006954 inflammatory response
GO:0006986 response to unfolded protein
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007252 I-kappaB phosphorylation
GO:0007257 activation of JUN kinase activity
GO:0008285 negative regulation of cell proliferation
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0010596 negative regulation of endothelial cell migration
GO:0010633 negative regulation of epithelial cell migration
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010976 positive regulation of neuron projection development
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016525 negative regulation of angiogenesis
GO:0021814 cell motility involved in cerebral cortex radial glia guided migration
GO:0021819 layer formation in cerebral cortex
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032312 regulation of ARF GTPase activity
GO:0032320 positive regulation of Ras GTPase activity
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0034260 negative regulation of GTPase activity
GO:0034261 negative regulation of Ras GTPase activity
GO:0035148 tube formation
GO:0035414 negative regulation of catenin import into nucleus
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043254 regulation of protein complex assembly
GO:0043407 negative regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043507 positive regulation of JUN kinase activity
GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity
GO:0044257 cellular protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045732 positive regulation of protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048147 negative regulation of fibroblast proliferation
GO:0048812 neuron projection morphogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070317 negative regulation of G0 to G1 transition
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071158 positive regulation of cell cycle arrest
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072577 endothelial cell apoptotic process
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090129 positive regulation of synapse maturation
GO:1900006 positive regulation of dendrite development
GO:1900744 regulation of p38MAPK cascade
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:2000599 negative regulation of cyclin catabolic process
GO:2001224 positive regulation of neuron migration
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0030139 endocytic vesicle
GO:0030424 axon
GO:0030425 dendrite
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane
GO:0032809 neuronal cell body membrane
GO:0043025 neuronal cell body
GO:0044300 cerebellar mossy fiber
GO:0044301 climbing fiber
GO:0070062 extracellular vesicular exosome
GO:1990032 parallel fiber
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026883
View Gene Order
ENSBTAG00000008232
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
ras_pathway
Regulation of Ras family activation
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.522378 Hs.707109 Hs.737098
RefSeq NM_032552 NM_138709 XM_005251719 XM_005251721 XM_005251722 XM_005251724 XM_005251725 XM_006716961 XM_006716962
HUGO
OMIM
CCDS CCDS6832 CCDS6833
HPRD 09903
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca