Version 5.4
Homo sapiens Gene: TLL2
Summary
InnateDB Gene IDBG-83775.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLL2
Gene Name tolloid-like 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000095587
Encoded Proteins
IDBP-83779
tolloid-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:96364606-96513918
Strand Reverse strand
Band q24.1
Transcripts
ENST00000357947 ENSP00000350630
ENST00000469598
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007275 multicellular organismal development
GO:0022617 extracellular matrix disassembly
GO:0030154 cell differentiation
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025013
View Gene Order
ENSBTAG00000011743
Not yet available
Pathways
NETPATH
REACTOME
REACT_150268
Anchoring fibril formation pathway
REACT_150206
Crosslinking of collagen fibrils pathway
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_120729
Collagen formation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9Y6L7
TrEMBL
UniProt Splice Variant
Entrez Gene 7093
UniGene Hs.154296
RefSeq NM_012465
HUGO HGNC:11844
OMIM 606743
CCDS CCDS7449
HPRD 05993
IMGT
EMBL AB023149 AF059516 AL136181 AL138765 AL391136 BC013871 BC112341 BC112366 BC113577
GenPept AAD42979 AAH13871 AAI12342 AAI12367 AAI13578 BAA76776 CAH72234 CAH72983 CAI13580
RNA Seq Atlas 7093

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca