Homo sapiens Gene: GNG13
Summary
InnateDB Gene IDBG-8382.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNG13
Gene Name guanine nucleotide binding protein (G protein), gamma 13
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000127588
Encoded Proteins
guanine nucleotide binding protein (G protein), gamma 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:798041-800733
Strand Reverse strand
Band p13.3
Transcripts
ENST00000248150 ENSP00000248150
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0031681 G-protein beta-subunit binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0044281 small molecule metabolic process
GO:0050909 sensory perception of taste
GO:0071377 cellular response to glucagon stimulus
Cellular Component
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Integration of energy metabolism pathway
ADP signalling through P2Y purinoceptor 12 pathway
Presynaptic function of Kainate receptors pathway
Transmembrane transport of small molecules pathway
G alpha (12/13) signalling events pathway
Thrombin signalling through proteinase activated receptors (PARs) pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
Ca2+ pathway pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
beta-catenin independent WNT signaling pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by GPCR pathway
Prostacyclin signalling through prostacyclin receptor pathway
Glucagon signaling in metabolic regulation pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Opioid Signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Incretin synthesis, secretion, and inactivation pathway
G alpha (i) signalling events pathway
Glucagon-type ligand receptors pathway
G-protein activation pathway
Activation of Kainate Receptors upon glutamate binding pathway
Metabolism of proteins pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Platelet homeostasis pathway
G alpha (z) signalling events pathway
Thromboxane signalling through TP receptor pathway
Transmission across Chemical Synapses pathway
ADP signalling through P2Y purinoceptor 1 pathway
G beta:gamma signalling through PLC beta pathway
GPCR ligand binding pathway
Regulation of insulin secretion pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Peptide hormone metabolism pathway
G beta:gamma signalling through PI3Kgamma pathway
Signal amplification pathway
Class B/2 (Secretin family receptors) pathway
Aquaporin-mediated transport pathway
Hemostasis pathway
KEGG
Chemokine signaling pathway pathway
Taste transduction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9P2W3
TrEMBL
UniProt Splice Variant
Entrez Gene 51764
UniGene Hs.247888
RefSeq NM_016541
HUGO HGNC:14131
OMIM 607298
CCDS CCDS10427
HPRD
IMGT
EMBL AB030207 AE006465 AF493880 AK312139 AL031033 AY029486 BC093760 BC095525
GenPept AAH93760 AAH95525 AAK40269 AAK61257 AAM12594 BAA92768 BAG35075 CAB53059
RNA Seq Atlas 51764