Version 5.4
Homo sapiens Gene: SPP2
Summary
InnateDB Gene IDBG-83947.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPP2
Gene Name secreted phosphoprotein 2, 24kDa
Synonyms SPP-24; SPP24
Species Homo sapiens
Ensembl Gene ENSG00000072080
Encoded Proteins
IDBP-83949
secreted phosphoprotein 2, 24kDa
IDBP-83953
secreted phosphoprotein 2, 24kDa
IDBP-389419
secreted phosphoprotein 2, 24kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a secreted phosphoprotein that is a member of the cystatin superfamily. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:234050679-234077134
Strand Forward strand
Band q37.1
Transcripts
ENST00000373368 ENSP00000362466
ENST00000168148 ENSP00000168148
ENST00000425558 ENSP00000417036
ENST00000492481
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
Biological Process
GO:0001501 skeletal system development
GO:0006461 protein complex assembly
GO:0010951 negative regulation of endopeptidase activity
GO:0046849 bone remodeling
Cellular Component
GO:0005576 extracellular region
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026295
View Gene Order
ENSBTAG00000002030
Not yet available
Cross-References
SwissProt Q13103
TrEMBL C9J6K0
UniProt Splice Variant
Entrez Gene 6694
UniGene Hs.444488
RefSeq NM_006944
HUGO HGNC:11256
OMIM 602637
CCDS CCDS2511
HPRD 04029
IMGT
EMBL AC006037 AJ272265 AJ308099 BC069401 BC106705 BC112438 CH471063 U20530
GenPept AAA87905 AAH69401 AAI06706 AAI12439 AAX93090 CAB75571 CAC87050 EAW71070
RNA Seq Atlas 6694

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca