InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UPF3B

Summary

InnateDB Gene

IDBG-83985.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UPF3B

Gene Name

UPF3 regulator of nonsense transcripts homolog B (yeast)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000125351

Encoded Proteins

IDBP-83987

UPF3 regulator of nonsense transcripts homolog B (yeast)

IDBP-83989

UPF3 regulator of nonsense transcripts homolog B (yeast)

IDBP-812975

UPF3 regulator of nonsense transcripts homolog B (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:119834022-119852998

Strand

Reverse strand

Band

q24

Transcripts

ENST00000276201	ENSP00000276201
ENST00000345865	ENSP00000245418
ENST00000478840
ENST00000619445	ENSP00000481698

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.

Experimentally validated
Total	51 [view]
Protein-Protein	50 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003729	mRNA binding
GO:0005487	nucleocytoplasmic transporter activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0031124	mRNA 3'-end processing
GO:0045727	positive regulation of translation