InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CXCR7

Summary

InnateDB Gene

IDBG-84146.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCR7

Gene Name

chemokine (C-X-C motif) receptor 7

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000144476

Encoded Proteins

IDBP-84148

chemokine (C-X-C motif) receptor 7

IDBP-389451

chemokine (C-X-C motif) receptor 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:236567787-236582358

Strand

Forward strand

Band

q37.3

Transcripts

ENST00000272928	ENSP00000272928
ENST00000447924	ENSP00000405945

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0015026	coreceptor activity
GO:0016494	C-X-C chemokine receptor activity
GO:0019958	C-X-C chemokine binding

Biological Process

GO:0001525	angiogenesis
GO:0001570	vasculogenesis
GO:0006935	chemotaxis
GO:0007155	cell adhesion
GO:0007186	G-protein coupled receptor signaling pathway
GO:0016032	viral process
GO:0031623	receptor internalization
GO:0070098	chemokine-mediated signaling pathway
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Cellular Component

GO:0005768	endosome
GO:0005769	early endosome
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000044337

View Gene Order

ENSBTAG00000018424

Not yet available

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_15344

Chemokine receptors bind chemokines pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_020311 XM_005246097 XM_005246098 XM_006712640

HUGO

OMIM

CCDS

CCDS2516

HPRD

09882

IMGT

EMBL

GenPept

RNA Seq Atlas