InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ISG15

Summary

InnateDB Gene

IDBG-84312.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ISG15

Gene Name

ISG15 ubiquitin-like modifier

Synonyms

G1P2; hUCRP; IFI15; IP17; UCRP

Species

Homo sapiens

Ensembl Gene

ENSG00000187608

Encoded Proteins

IDBP-84314

ISG15 ubiquitin-like modifier

IDBP-809794

ISG15 ubiquitin-like modifier

IDBP-809796

ISG15 ubiquitin-like modifier

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19043203

ISG15 (ISGylation) post-translational modification is mediated by a sequential reaction similar to ubiquitination and has been shown to negatively regulate the NF-kappaB pathway.

PMID 22022264

ISG15 expression is induced during a hepatitis C virus infection in an IRF3-dependent manner. ISG15 acts as a negative modulator of the RIG-I pathway by mediating the level of DDX58 (RIG-I) ubiquitination.

PMID 24448099

ISG15 does not directly alter human rhinovirus replication but modulates immune signalling via the viral sensor protein DDX58 to impact production of CXCL10, which has been linked to innate immunity to viruses.

PMID 24448099

Human rhinovirus infection of epithelial cells induces the expression and secretion of ISG15, which modulates immune responses via effects on DDX58, and by regulating CXCL10 production.

PMID 26259872

ISG15 protects against Listeria monocytogenes infection.

InnateDB Annotation from Orthologs

Summary

PMID 22022264

[Mus musculus] Isg15 expression is induced during a hepatitis C virus infection in an Irf3-dependent manner. Isg15 acts as a negative modulator of the RIG-I pathway by mediating the level of Ddx58 (RIG-I) ubiquitination. (Demonstrated in human)

PMID 26259872

[Mus musculus] Isg15 protects against Listeria monocytogenes infection.

Entrez Gene

Summary

The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:1001138-1014541

Strand

Forward strand

Band

p36.33

Transcripts

ENST00000379389	ENSP00000368699
ENST00000624697	ENSP00000485643
ENST00000624652	ENSP00000485313

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 244 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	244 [view]
Protein-Protein	214 [view]
Protein-DNA	30 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031386	protein tag

Biological Process

GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0019941	modification-dependent protein catabolic process
GO:0031397	negative regulation of protein ubiquitination
GO:0032020	ISG15-protein conjugation
GO:0032480	negative regulation of type I interferon production
GO:0032649	regulation of interferon-gamma production
GO:0034340	response to type I interferon
GO:0042742	defense response to bacterium
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045648	positive regulation of erythrocyte differentiation
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway