Homo sapiens Gene: OSBPL2
Summary
InnateDB Gene IDBG-84315.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSBPL2
Gene Name oxysterol binding protein-like 2
Synonyms ORP-2; ORP2;
Species Homo sapiens
Ensembl Gene ENSG00000130703
Encoded Proteins
oxysterol binding protein-like 2
oxysterol binding protein-like 2
oxysterol binding protein-like 2
oxysterol binding protein-like 2
oxysterol binding protein-like 2
oxysterol binding protein-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:62231922-62296213
Strand Forward strand
Band q13.33
Transcripts
ENST00000313733 ENSP00000316649
ENST00000358053 ENSP00000350755
ENST00000439951 ENSP00000397602
ENST00000448156 ENSP00000415751
ENST00000471817
ENST00000615516
ENST00000618509 ENSP00000479702
ENST00000622332 ENSP00000478158
ENST00000618198
ENST00000620616
ENST00000621075
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015485 cholesterol binding
Biological Process
GO:0006869 lipid transport
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 9885
UniGene
RefSeq NM_144498 NM_014835 NM_001278649 XM_005260625
HUGO HGNC:15761
OMIM 606731
CCDS CCDS13495 CCDS13494 CCDS63323
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 400850 9885