InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADRM1

Summary

InnateDB Gene

IDBG-84373.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRM1

Gene Name

adhesion regulating molecule 1

Synonyms

ARM-1; ARM1; GP110

Species

Homo sapiens

Ensembl Gene

ENSG00000130706

Encoded Proteins

IDBP-84375

adhesion regulating molecule 1

IDBP-812153

adhesion regulating molecule 1

IDBP-812155

adhesion regulating molecule 1

IDBP-812159

adhesion regulating molecule 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is an integral plasma membrane protein which promotes cell adhesion. The encoded protein is thought to undergo O-linked glycosylation. Expression of this gene has been shown to be induced by gamma interferon in some cancer cells. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:62302093-62308862

Strand

Forward strand

Band

q13.33

Transcripts

ENST00000253003	ENSP00000253003
ENST00000491935	ENSP00000478877
ENST00000462554	ENSP00000479008
ENST00000465805
ENST00000620230	ENSP00000480756

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	69 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0061133	endopeptidase activator activity
GO:0070628	proteasome binding

Biological Process

GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010950	positive regulation of endopeptidase activity
GO:0043248	proteasome assembly

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000039041

View Gene Order

ENSBTAG00000003058

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

deltanp63pathway

Validated transcriptional targets of deltaNp63 isoforms

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001281437 NM_001281438 NM_007002 NM_175573 XM_005260257

HUGO

OMIM

CCDS

CCDS13496 CCDS74747

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas