Version 5.4
Homo sapiens Gene: CUL4B
Summary
InnateDB Gene IDBG-84499.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CUL4B
Gene Name cullin 4B
Synonyms CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2
Species Homo sapiens
Ensembl Gene ENSG00000158290
Encoded Proteins
IDBP-84501
cullin 4B
IDBP-84503
cullin 4B
IDBP-84505
cullin 4B
IDBP-295158
cullin 4B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:120524609-120575794
Strand Reverse strand
Band q24
Transcripts
ENST00000336592 ENSP00000338919
ENST00000371323 ENSP00000360374
ENST00000371322 ENSP00000360373
ENST00000404115 ENSP00000384109
ENST00000497616
ENST00000467641
ENST00000486604
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 345 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 345 [view]
Protein-Protein 345 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007049 cell cycle
GO:0035518 histone H2A monoubiquitination
GO:0045732 positive regulation of protein catabolic process
GO:0070914 UV-damage excision repair
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031465 Cul4B-RING E3 ubiquitin ligase complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031095
View Gene Order
ENSBTAG00000018569
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa03420
Nucleotide excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.102914 Hs.622692
RefSeq NM_001079872 NM_003588 XM_005262481 XM_006724784 XM_006724785
HUGO
OMIM
CCDS CCDS35379 CCDS43987
HPRD 02251
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca