Version 5.4
Homo sapiens Gene: MAPK14
Summary
InnateDB Gene IDBG-84613.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPK14
Gene Name mitogen-activated protein kinase 14
Synonyms CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38; p38ALPHA; PRKM14; PRKM15; RK; SAPK2A
Species Homo sapiens
Ensembl Gene ENSG00000112062
Encoded Proteins
IDBP-84615
mitogen-activated protein kinase 14
IDBP-84617
mitogen-activated protein kinase 14
IDBP-84619
mitogen-activated protein kinase 14
IDBP-484826
mitogen-activated protein kinase 14
IDBP-479174
mitogen-activated protein kinase 14
IDBP-478774
mitogen-activated protein kinase 14
IDBP-481745
mitogen-activated protein kinase 14
IDBP-811975
mitogen-activated protein kinase 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 15569672
MAPK14 is dephosphorylated by PPP2R4, which then induces apoptosis in neutrophils and the resolution of inflammation.
PMID 21683629
MAPK14 activation is blocked by Bacillus anthracis, resulting in the opening of a connexin ATP release channel and induction of macrophage death. Constitutive activation of MAPK14 interferes with inflammasome activation and IL1B production, which compromises antimicrobial immunity. (Demonstrated in murine model)
PMID 21733175
The MAPK14 pathway is an important contributor to microglial production of proinflammatory cytokines induced by LPS or beta-amyloid. (Demonstrated in mouse)
PMID 22028692
MAPK14 mediates cytoskeletal remodelling and early spreading of lipopolysaccharide (LPS)-stimulated macrophages. (Demonstrated in mice)
PMID 22447027
MAPK1 (ERK) and MAPK14 (p38) control the dynamic balance regulating neutrophil migration.
PMID 25642820
Mycobacterium tuberculosis phosphatase PtpA suppresses innate immunity by binding to ubiquitin; which, in turn, activates it to dephosphorylate phosphorylated MAPK8 and MAPK14.
InnateDB Annotation from Orthologs
Summary
PMID 21683629
[Mus musculus] Mapk14 activation is blocked by Bacillus anthracis, resulting in the opening of a connexin ATP release channel and induction of macrophage death. Constitutive activation of Mapk14 interferes with inflammasome activation and Il1b production, which compromises antimicrobial immunity.
PMID 21733175
[Mus musculus] The Mapk14 pathway is an important contributor to microglial production of proinflammatory cytokines induced by LPS or beta-amyloid.
PMID 22028692
[Mus musculus] Mapk14 mediates cytoskeletal remodelling and early spreading of lipopolysaccharide (LPS)-stimulated macrophages.
PMID 22447027
[Mus musculus] Mapk1 (ERK) and Mapk14 (p38) control the dynamic balance regulating neutrophil migration. (Demonstrated in human)
PMID 25783839
[Mus musculus] Lysophosphatidic acid plays an anti-inflammatory role in macrophages by diminishing lipopolysaccharide-induced phosphorylation of Mapk14 and Akt1, as well as Rela nuclear translocation.
PMID 25848864
[Mus musculus] Treml4 is an essential positive regulator of Tlr7 signalling. Treml4(-/-) macrophages are hyporesponsive to Tlr7 agonists and fail to produce type I interferons due to impaired phosphorylation of Stat1 by Mapk14 and decreased recruitment of Myd88 to Tlr7.
Entrez Gene
Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:36027677-36111236
Strand Forward strand
Band p21.31
Transcripts
ENST00000229794 ENSP00000229794
ENST00000229795 ENSP00000229795
ENST00000310795 ENSP00000308669
ENST00000468133 ENSP00000419837
ENST00000496250
ENST00000491957 ENSP00000417531
ENST00000474429 ENSP00000417065
ENST00000472333 ENSP00000419141
ENST00000490379
ENST00000622903 ENSP00000478079
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 255 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 255 [view]
Protein-Protein 253 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0051525 NFAT protein binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0000902 cell morphogenesis
GO:0001502 cartilage condensation
GO:0001525 angiogenesis
GO:0002062 chondrocyte differentiation
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006006 glucose metabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006928 cellular component movement
GO:0006935 chemotaxis
GO:0006974 cellular response to DNA damage stimulus
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007519 skeletal muscle tissue development
GO:0007596 blood coagulation
GO:0009103 lipopolysaccharide biosynthetic process
GO:0010467 gene expression
GO:0010831 positive regulation of myotube differentiation
GO:0014835 myoblast differentiation involved in skeletal muscle regeneration
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0018105 peptidyl-serine phosphorylation
GO:0019395 fatty acid oxidation
GO:0030168 platelet activation
GO:0030316 osteoclast differentiation
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032495 response to muramyl dipeptide
GO:0032496 response to lipopolysaccharide
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035556 intracellular signal transduction
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038066 p38MAPK cascade
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042307 positive regulation of protein import into nucleus
GO:0042692 muscle cell differentiation
GO:0042770 signal transduction in response to DNA damage
GO:0045087 innate immune response (InnateDB)
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051403 stress-activated MAPK cascade
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0071222 cellular response to lipopolysaccharide
GO:0071479 cellular response to ionizing radiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090400 stress-induced premature senescence
GO:1901741 positive regulation of myoblast fusion
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0000922 spindle pole
GO:0005623 cell
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053436
View Gene Order
ENSBTAG00000020783
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_13
IL1 pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_17
IL5 pathway
NetPath_18
IL6 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_24
TSLP pathway
NetPath_25
FSH pathway
NetPath_26
TWEAK pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_12599
ERK/MAPK targets pathway
REACT_21326
Activation of the AP-1 family of transcription factors pathway
REACT_21399
activated TAK1 mediates p38 MAPK activation pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_75776
NOD1/2 Signaling Pathway pathway
REACT_23879
Platelet sensitization by LDL pathway
REACT_23876
Platelet homeostasis pathway
REACT_19140
ADP signalling through P2Y purinoceptor 1 pathway
REACT_12065
p38MAPK events pathway
REACT_12033
Signalling to RAS pathway
REACT_25042
KSRP destabilizes mRNA pathway
REACT_25299
DSCAM interactions pathway
REACT_21402
CDO in myogenesis pathway
REACT_120956
Cellular responses to stress pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_111155
Cell-Cell communication pathway
REACT_200686
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
REACT_12529
Signaling by VEGF pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_21303
Myogenesis pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_12433
Nuclear Events (kinase and transcription factor activation) pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_20524
Signal amplification pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_71
Gene Expression pathway
REACT_604
Hemostasis pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04010
MAPK signaling pathway pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
hsa04621
NOD-like receptor signaling pathway pathway
hsa05140
Leishmaniasis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
hsa05131
Shigellosis pathway
hsa05145
Toxoplasmosis pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
nfkappabatypicalpathway
Atypical NF-kappaB pathway
mapktrkpathway
Trk receptor signaling mediated by the MAPK pathway
s1p_s1p2_pathway
S1P2 pathway
il12_2pathway
IL12-mediated signaling events
atf2_pathway
ATF-2 transcription factor network
p53regulationpathway
p53 pathway
epopathway
EPO signaling pathway
rac1_pathway
RAC1 signaling pathway
fgf_pathway
FGF signaling pathway
endothelinpathway
Endothelins
bcr_5pathway
BCR signaling pathway
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
retinoic_acid_pathway
Retinoic acid receptors-mediated signaling
il4_2pathway
IL4-mediated signaling events
cdc42_pathway
CDC42 signaling events
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
p38alphabetapathway
Regulation of p38-alpha and p38-beta
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
ar_tf_pathway
Regulation of Androgen receptor activity
p38_mk2pathway
p38 signaling mediated by MAPKAP kinases
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.485233 Hs.608728 Hs.719314
RefSeq NM_001315 NM_139012 NM_139014 XM_006714998
HUGO
OMIM
CCDS CCDS4815 CCDS4816 CCDS4817
HPRD 02619
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca