InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPS21

Summary

InnateDB Gene

IDBG-84671.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS21

Gene Name

ribosomal protein S21

Synonyms

HLDF; S21

Species

Homo sapiens

Ensembl Gene

ENSG00000171858

Encoded Proteins

IDBP-84675

ribosomal protein S21

IDBP-84677

ribosomal protein S21

IDBP-84681

ribosomal protein S21

IDBP-380293

ribosomal protein S21

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:62387116-62388520

Strand

Forward strand

Band

q13.33

Transcripts

ENST00000370592	ENSP00000359624
ENST00000343986	ENSP00000345957
ENST00000370562	ENSP00000359593
ENST00000450116	ENSP00000388332
ENST00000492356

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.

Experimentally validated
Total	106 [view]
Protein-Protein	103 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0044822	poly(A) RNA binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0042274	ribosomal small subunit biogenesis
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0022627	cytosolic small ribosomal subunit