InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AGXT

Summary

InnateDB Gene

IDBG-84952.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGXT

Gene Name

alanine-glyoxylate aminotransferase

Synonyms

AGT; AGT1; AGXT1; PH1; SPAT; SPT; TLH6

Species

Homo sapiens

Ensembl Gene

ENSG00000172482

Encoded Proteins

IDBP-84954

alanine-glyoxylate aminotransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:240868479-240880502

Strand

Forward strand

Band

q37.3

Transcripts

ENST00000307503	ENSP00000302620
ENST00000472436
ENST00000476698
ENST00000470255

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004760	serine-pyruvate transaminase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008453	alanine-glyoxylate transaminase activity
GO:0008483	transaminase activity
GO:0016597	amino acid binding
GO:0030170	pyridoxal phosphate binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006625	protein targeting to peroxisome
GO:0008152	metabolic process
GO:0009436	glyoxylate catabolic process
GO:0019265	glycine biosynthetic process, by transamination of glyoxylate
GO:0019448	L-cysteine catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0042853	L-alanine catabolic process
GO:0042866	pyruvate biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046487	glyoxylate metabolic process
GO:0046724	oxalic acid secretion
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005777	peroxisome
GO:0005782	peroxisomal matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026272

View Gene Order

ENSBTAG00000005797

Not yet available

Pathways

NETPATH

REACTOME

REACT_16925

Glyoxylate metabolism pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00260

Glycine, serine and threonine metabolism pathway

hsa00630

Glyoxylate and dicarboxylate metabolism pathway

hsa00250

Alanine, aspartate and glutamate metabolism pathway

hsa04146

Peroxisome pathway

INOH

INOH website

Glycolysis Gluconeogenesis pathway

INOH website

Alanine Aspartate Asparagine metabolism pathway

INOH website

Glycine Serine metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.144567

RefSeq

NM_000030

HUGO

OMIM

CCDS

CCDS2543

HPRD

05048

IMGT

EMBL

GenPept

RNA Seq Atlas