InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SRSF3

Summary

InnateDB Gene

IDBG-84998.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRSF3

Gene Name

serine/arginine-rich splicing factor 3

Synonyms

SFRS3; SRp20

Species

Homo sapiens

Ensembl Gene

ENSG00000112081

Encoded Proteins

IDBP-85000

serine/arginine-rich splicing factor 3

IDBP-592586

serine/arginine-rich splicing factor 3

IDBP-809025

serine/arginine-rich splicing factor 3

IDBP-809032

serine/arginine-rich splicing factor 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:36594353-36605600

Strand

Forward strand

Band

p21.31

Transcripts

ENST00000373715	ENSP00000362820
ENST00000339436
ENST00000477442	ENSP00000436036
ENST00000613941	ENSP00000484891
ENST00000620242
ENST00000620941	ENSP00000482833
ENST00000620389
ENST00000614136

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.

Experimentally validated
Total	124 [view]
Protein-Protein	122 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0043274	phospholipase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing