Homo sapiens Gene: NEU4
Summary
InnateDB Gene IDBG-85340.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEU4
Gene Name sialidase 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204099
Encoded Proteins
sialidase 4
sialidase 4
sialidase 4
sialidase 4
sialidase 4
sialidase 4
sialidase 4
sialidase 4
sialidase 4
sialidase 4
sialidase 4
sialidase 4
sialidase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:241808825-241817413
Strand Forward strand
Band q37.3
Transcripts
ENST00000325935 ENSP00000320318
ENST00000391969 ENSP00000375830
ENST00000407683 ENSP00000385402
ENST00000405370 ENSP00000384804
ENST00000404257 ENSP00000385149
ENST00000415936 ENSP00000397167
ENST00000435855 ENSP00000394769
ENST00000423583 ENSP00000397860
ENST00000435934 ENSP00000412688
ENST00000426032 ENSP00000406678
ENST00000435894 ENSP00000398571
ENST00000420288 ENSP00000388707
ENST00000428592 ENSP00000396197
ENST00000476542
ENST00000494678
ENST00000488997
ENST00000618597
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004308 exo-alpha-sialidase activity
GO:0005515 protein binding
GO:0052794 exo-alpha-(2->3)-sialidase activity
GO:0052795 exo-alpha-(2->6)-sialidase activity
GO:0052796 exo-alpha-(2->8)-sialidase activity
Biological Process
GO:0006516 glycoprotein catabolic process
GO:0006665 sphingolipid metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0006689 ganglioside catabolic process
GO:0008152 metabolic process
GO:0009313 oligosaccharide catabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0019866 organelle inner membrane
GO:0043202 lysosomal lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
Synthesis of substrates in N-glycan biosythesis pathway
Asparagine N-linked glycosylation pathway
Sialic acid metabolism pathway
Metabolism of proteins pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
KEGG
Other glycan degradation pathway
Sphingolipid metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8WWR8
TrEMBL B3KR54 C9J2V4 C9J5X2 C9JRN9
UniProt Splice Variant
Entrez Gene 129807
UniGene Hs.551747
RefSeq NM_001167599 NM_001167601 NM_001167600 NM_080741 NM_001167602
HUGO HGNC:21328
OMIM 608527
CCDS CCDS54441 CCDS54442 CCDS2553
HPRD 12249
IMGT
EMBL AC114730 AJ277883 AK091038 AK289421 AK300969 AY203952 BC012899 CH471063
GenPept AAH12899 AAP34475 AAX82022 BAF82110 BAG52266 BAH13385 CAC81904 EAW71295 EAW71296
RNA Seq Atlas 129807