Homo sapiens Gene: OGFR
Summary
InnateDB Gene IDBG-85351.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OGFR
Gene Name opioid growth factor receptor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000060491
Encoded Proteins
opioid growth factor receptor
opioid growth factor receptor
opioid growth factor receptor
opioid growth factor receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:62804835-62814000
Strand Forward strand
Band q13.33
Transcripts
ENST00000290291 ENSP00000290291
ENST00000370461 ENSP00000359491
ENST00000450048 ENSP00000395168
ENST00000621591 ENSP00000483055
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 15 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004985 opioid receptor activity
Biological Process
GO:0001558 regulation of cell growth
GO:0038003 opioid receptor signaling pathway
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9NZT2
TrEMBL Q4VXW3
UniProt Splice Variant
Entrez Gene 11054
UniGene
RefSeq NM_007346
HUGO HGNC:15768
OMIM 606459
CCDS CCDS13504
HPRD 08404
IMGT
EMBL AF109134 AF112980 AF172451 AF172452 AF172453 AK024485 AL035669 BC014137
GenPept AAD03737 AAD03745 AAF64404 AAF64405 AAF64406 AAH14137 BAB15775 CAC28882 CAI95763
RNA Seq Atlas 11054