Version 5.4
Homo sapiens Gene: NKX2-3
Summary
InnateDB Gene IDBG-86031.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NKX2-3
Gene Name NK2 homeobox 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000119919
Encoded Proteins
IDBP-86033
NK2 homeobox 3
IDBP-812676
NK2 homeobox 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.[provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:99532933-99536524
Strand Forward strand
Band q24.2
Transcripts
ENST00000344586 ENSP00000342828
ENST00000622383 ENSP00000479692
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001776 leukocyte homeostasis
GO:0002317 plasma cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006641 triglyceride metabolic process
GO:0006955 immune response
GO:0008150 biological_process
GO:0009791 post-embryonic development
GO:0022612 gland morphogenesis
GO:0030183 B cell differentiation
GO:0030225 macrophage differentiation
GO:0042127 regulation of cell proliferation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043367 CD4-positive, alpha-beta T cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048535 lymph node development
GO:0048536 spleen development
GO:0048537 mucosal-associated lymphoid tissue development
GO:0048541 Peyer's patch development
GO:0048565 digestive tract development
GO:0048621 post-embryonic digestive tract morphogenesis
GO:0050900 leukocyte migration
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044220
View Gene Order
ENSBTAG00000021397
Not yet available
Cross-References
SwissProt Q8TAU0
TrEMBL
UniProt Splice Variant
Entrez Gene 159296
UniGene Hs.243272
RefSeq NM_145285
HUGO HGNC:7836
OMIM 606727
CCDS CCDS41558
HPRD 05992
IMGT
EMBL AH009193 AK300856 AL353719 BC025788
GenPept AAF44651 AAH25788 BAG62506 CAI16899
RNA Seq Atlas 159296

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca