InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ABCC2

Summary

InnateDB Gene

IDBG-86121.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCC2

Gene Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Synonyms

ABC30; CMOAT; cMRP; DJS; MRP2

Species

Homo sapiens

Ensembl Gene

ENSG00000023839

Encoded Proteins

IDBP-86123

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

IDBP-86125

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:99782732-99852192

Strand

Forward strand

Band

q24.2

Transcripts

ENST00000370449	ENSP00000359478
ENST00000370434	ENSP00000359463
ENST00000496621

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	47 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008514	organic anion transmembrane transporter activity
GO:0016887	ATPase activity
GO:0019904	protein domain specific binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0006855	drug transmembrane transport
GO:0006979	response to oxidative stress
GO:0009408	response to heat
GO:0015732	prostaglandin transport
GO:0030644	cellular chloride ion homeostasis
GO:0031427	response to methotrexate
GO:0042493	response to drug
GO:0043627	response to estrogen
GO:0046685	response to arsenic-containing substance
GO:0055085	transmembrane transport
GO:0070327	thyroid hormone transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0046581	intercellular canaliculus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025194

View Gene Order

ENSBTAG00000008936

Not yet available

Pathways

NETPATH

REACTOME

REACT_15480

ABC-family proteins mediated transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

KEGG

hsa02010

ABC transporters pathway

hsa04976

Bile secretion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.368243

RefSeq

NM_000392 XM_006717630 XM_006717631

HUGO

OMIM

CCDS

CCDS7484

HPRD

03065

IMGT

EMBL

GenPept

RNA Seq Atlas