InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: STXBP1

Summary

InnateDB Gene

IDBG-86143.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STXBP1

Gene Name

syntaxin binding protein 1

Synonyms

MUNC18-1; NSEC1; P67; RBSEC1; UNC18

Species

Homo sapiens

Ensembl Gene

ENSG00000136854

Encoded Proteins

IDBP-86145

syntaxin binding protein 1

IDBP-86147

syntaxin binding protein 1

IDBP-807251

syntaxin binding protein 1

IDBP-807252

syntaxin binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:127612265-127692716

Strand

Forward strand

Band

q34.11

Transcripts

ENST00000373302	ENSP00000362399
ENST00000373299	ENSP00000362396
ENST00000476182
ENST00000496504	ENSP00000485361
ENST00000494254	ENSP00000485397

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005515	protein binding
GO:0017075	syntaxin-1 binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0019905	syntaxin binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0002576	platelet degranulation
GO:0006112	energy reserve metabolic process
GO:0006887	exocytosis
GO:0006904	vesicle docking involved in exocytosis
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007274	neuromuscular synaptic transmission
GO:0007412	axon target recognition
GO:0010807	regulation of synaptic vesicle priming
GO:0014047	glutamate secretion
GO:0015031	protein transport
GO:0016188	synaptic vesicle maturation
GO:0016192	vesicle-mediated transport
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0043524	negative regulation of neuron apoptotic process
GO:0044281	small molecule metabolic process
GO:0045921	positive regulation of exocytosis
GO:0045956	positive regulation of calcium ion-dependent exocytosis
GO:0050796	regulation of insulin secretion
GO:0050821	protein stabilization
GO:0060292	long term synaptic depression
GO:0070527	platelet aggregation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0031091	platelet alpha granule
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026797

View Gene Order

ENSBTAG00000003525

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

REACT_18325

Regulation of insulin secretion pathway

REACT_1505

Integration of energy metabolism pathway

REACT_111217

Metabolism pathway

KEGG

INOH

PID NCI

botulinumtoxinpathway

Effects of Botulinum toxin

Cross-References

SwissProt

P61764

TrEMBL

UniProt Splice Variant

Entrez Gene

6812

UniGene

Hs.288229

RefSeq

NM_003165 NM_001032221

HUGO

HGNC:11444

OMIM

602926

CCDS

CCDS6874 CCDS35146

HPRD

04235

IMGT

EMBL

AF004562 AF004563 AL162426 BC015749 CH471090 D63851

GenPept

AAC39688 AAC39689 AAH15749 BAA19483 CAI41180 EAW87681

RNA Seq Atlas

6812