Version 5.4
Homo sapiens Gene: PTK6
Summary
InnateDB Gene IDBG-86381.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTK6
Gene Name PTK6 protein tyrosine kinase 6
Synonyms BRK
Species Homo sapiens
Ensembl Gene ENSG00000101213
Encoded Proteins
IDBP-86383
PTK6 protein tyrosine kinase 6
IDBP-589327
PTK6 protein tyrosine kinase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:63528001-63537370
Strand Reverse strand
Band q13.33
Transcripts
ENST00000217185 ENSP00000217185
ENST00000542869 ENSP00000442460
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042802 identical protein binding
Biological Process
GO:0006468 protein phosphorylation
GO:0010976 positive regulation of neuron projection development
GO:0016477 cell migration
GO:0042503 tyrosine phosphorylation of Stat3 protein
GO:0042506 tyrosine phosphorylation of Stat5 protein
GO:0045926 negative regulation of growth
GO:0046777 protein autophosphorylation
GO:0060575 intestinal epithelial cell differentiation
GO:0061099 negative regulation of protein tyrosine kinase activity
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038751
View Gene Order
ENSBTAG00000044091
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q13882
TrEMBL
UniProt Splice Variant
Entrez Gene 5753
UniGene Hs.51133
RefSeq NM_005975 NM_001256358
HUGO HGNC:9617
OMIM 602004
CCDS CCDS13524 CCDS74750
HPRD 03594
IMGT
EMBL AK301364 AK315232 AL121829 BC035843 U61406 U61407 U61408 U61409 U61410 U61411 U61412 X78549
GenPept AAC34935 AAH35843 BAG37660 BAG62908 CAA55295 CAC15525
RNA Seq Atlas 5753

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca