Version 5.4
Homo sapiens Gene: TNFRSF14
Summary
InnateDB Gene IDBG-86399.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF14
Gene Name tumor necrosis factor receptor superfamily, member 14
Synonyms ATAR; CD270; HVEA; HVEM; LIGHTR; TR2
Species Homo sapiens
Ensembl Gene ENSG00000157873
Encoded Proteins
IDBP-86401
tumor necrosis factor receptor superfamily, member 14
IDBP-292369
tumor necrosis factor receptor superfamily, member 14
IDBP-363361
tumor necrosis factor receptor superfamily, member 14
IDBP-363368
tumor necrosis factor receptor superfamily, member 14
IDBP-363369
tumor necrosis factor receptor superfamily, member 14
IDBP-363372
tumor necrosis factor receptor superfamily, member 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. [provided by RefSeq, Jul 2008]
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:2555639-2565382
Strand Forward strand
Band p36.32
Transcripts
ENST00000355716 ENSP00000347948
ENST00000409119 ENSP00000386859
ENST00000426449 ENSP00000411854
ENST00000434817 ENSP00000415254
ENST00000435221 ENSP00000399292
ENST00000451778 ENSP00000399533
ENST00000442392
ENST00000475523
ENST00000482074
ENST00000496064
ENST00000463471
ENST00000466750
ENST00000471768
ENST00000463835
ENST00000482602
ENST00000480305
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 51 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0002741 positive regulation of cytokine secretion involved in immune response
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0009615 response to virus
GO:0016032 viral process
GO:0031295 T cell costimulation
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0046642 negative regulation of alpha-beta T cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:2000406 positive regulation of T cell migration
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000042333
View Gene Order
Pathways
NETPATH
REACTOME
REACT_19344
Costimulation by the CD28 family pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.512898
RefSeq NM_003820 XM_006711020 XM_006724948
HUGO
OMIM
CCDS CCDS44046
HPRD 04122
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca