Homo sapiens Gene: HS6ST2
Summary
InnateDB Gene IDBG-86645.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HS6ST2
Gene Name heparan sulfate 6-O-sulfotransferase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171004
Encoded Proteins
heparan sulfate 6-O-sulfotransferase 2
heparan sulfate 6-O-sulfotransferase 2
heparan sulfate 6-O-sulfotransferase 2
heparan sulfate 6-O-sulfotransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration. This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:132626016-132961395
Strand Reverse strand
Band q26.2
Transcripts
ENST00000370836 ENSP00000359873
ENST00000370833 ENSP00000359870
ENST00000406696 ENSP00000384013
ENST00000521489 ENSP00000429473
ENST00000602570
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
GO:0017095 heparan sulfate 6-O-sulfotransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006024 glycosaminoglycan biosynthetic process
GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification
GO:0030203 glycosaminoglycan metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Mucopolysaccharidoses pathway
Myoclonic epilepsy of Lafora pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective CHST6 causes MCDC1 pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective PAPSS2 causes SEMD-PA pathway
Metabolism of carbohydrates pathway
MPS IIID - Sanfilippo syndrome D pathway
Defective SLC26A2 causes chondrodysplasias pathway
HS-GAG biosynthesis pathway
MPS IX - Natowicz syndrome pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Defective CHST14 causes EDS, musculocontractural type pathway
Heparan sulfate/heparin (HS-GAG) metabolism pathway
MPS IV - Morquio syndrome B pathway
Defective B3GAT3 causes JDSSDHD pathway
Defective CHST3 causes SEDCJD pathway
MPS IV - Morquio syndrome A pathway
Defective EXT2 causes exostoses 2 pathway
Diseases associated with glycosaminoglycan metabolism pathway
MPS II - Hunter syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Glycosaminoglycan metabolism pathway
Diseases of glycosylation pathway
MPS VII - Sly syndrome pathway
Defective CHSY1 causes TPBS pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIIA - Sanfilippo syndrome A pathway
MPS IIIC - Sanfilippo syndrome C pathway
Disease pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
Glycosaminoglycan biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q96MM7
TrEMBL B7Z2U5
UniProt Splice Variant
Entrez Gene 90161
UniGene
RefSeq NM_001077188 NM_147175 XM_006724790
HUGO HGNC:19133
OMIM 300545
CCDS CCDS48169 CCDS48170
HPRD
IMGT
EMBL AB067776 AB067777 AK027720 AK056706 AK075402 AK295118 AL022159 AL022309 AL831923 BC037325 BC094718 BC110620 BC110621 Z81365 Z82205 Z86064
GenPept AAH37325 AAH94718 AAI10621 AAI10622 BAB55322 BAB71260 BAC07183 BAC07184 BAC11597 BAH11981 CAD38583 CAI42774 CAI42775 CAX30811 CAX30812
RNA Seq Atlas 90161