Homo sapiens Gene: MED20
Summary
InnateDB Gene IDBG-86965.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED20
Gene Name mediator complex subunit 20
Synonyms PRO0213; TRFP;
Species Homo sapiens
Ensembl Gene ENSG00000124641
Encoded Proteins
mediator complex subunit 20
mediator complex subunit 20
mediator complex subunit 20
mediator complex subunit 20
mediator complex subunit 20
mediator complex subunit 20
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MED20 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al., 2003 [PubMed 14576168]).[supplied by OMIM, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:41905354-41921139
Strand Reverse strand
Band p21.1
Transcripts
ENST00000265350 ENSP00000265350
ENST00000394251 ENSP00000377795
ENST00000409312 ENSP00000386816
ENST00000409060 ENSP00000386668
ENST00000434077 ENSP00000403061
ENST00000467535
ENST00000482361
ENST00000613074 ENSP00000484159
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 34 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0003899 DNA-directed RNA polymerase activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0010467 gene expression
Cellular Component
GO:0005654 nucleoplasm
GO:0016592 mediator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Metabolism of lipids and lipoproteins pathway
PPARA activates gene expression pathway
Generic Transcription Pathway pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Transcriptional regulation of white adipocyte differentiation pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.278434
RefSeq NM_004275
HUGO
OMIM
CCDS CCDS4862
HPRD 15638
IMGT
EMBL
GenPept
RNA Seq Atlas