Version 5.4
Homo sapiens Gene: CCND3
Summary
InnateDB Gene IDBG-86973.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCND3
Gene Name cyclin D3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112576
Encoded Proteins
IDBP-86975
cyclin D3
IDBP-86977
cyclin D3
IDBP-86979
cyclin D3
IDBP-378676
cyclin D3
IDBP-378678
cyclin D3
IDBP-482734
cyclin D3
IDBP-481129
cyclin D3
IDBP-477292
cyclin D3
IDBP-475026
cyclin D3
IDBP-482560
cyclin D3
IDBP-474926
cyclin D3
IDBP-479255
cyclin D3
IDBP-809140
cyclin D3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:41934933-42050357
Strand Reverse strand
Band p21.1
Transcripts
ENST00000372991 ENSP00000362082
ENST00000372988 ENSP00000362079
ENST00000372987 ENSP00000362078
ENST00000415497 ENSP00000401595
ENST00000414200 ENSP00000397545
ENST00000511642 ENSP00000426212
ENST00000510503 ENSP00000425986
ENST00000511686
ENST00000512426 ENSP00000421511
ENST00000513956
ENST00000506555
ENST00000508143 ENSP00000423242
ENST00000505064 ENSP00000425830
ENST00000510058
ENST00000505672
ENST00000511161
ENST00000505884
ENST00000514382
ENST00000502771 ENSP00000425334
ENST00000514588 ENSP00000420991
ENST00000512381
ENST00000612455
ENST00000616010 ENSP00000484424
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 56 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001934 positive regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0042098 T cell proliferation
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051301 cell division
GO:0051726 regulation of cell cycle
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034165
View Gene Order
ENSBTAG00000010106
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_12
BCR pathway
NetPath_23
TSH pathway
REACTOME
REACT_821
Cyclin D associated events in G1 pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_1590
G1 Phase pathway
REACT_111045
Developmental Biology pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_115566
Cell Cycle pathway
REACT_152
Cell Cycle, Mitotic pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04110
Cell cycle pathway
hsa04510
Focal adhesion pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
e2f_pathway
E2F transcription factor network
il2_stat5pathway
IL2 signaling events mediated by STAT5
Cross-References
SwissProt P30281
TrEMBL D6RDL3 D6RIX2
UniProt Splice Variant
Entrez Gene 896
UniGene Hs.597485
RefSeq NM_001136017 NM_001136125 NM_001136126 NM_001287427 NM_001287434 NM_001760
HUGO HGNC:1585
OMIM 123834
CCDS CCDS47426 CCDS47425 CCDS47427 CCDS4863 CCDS75452
HPRD 00452
IMGT
EMBL AF517525 AK057206 AK097856 AK315421 AL160163 AL513008 BC011616 BX400719 CH471081 CR542246 M88084 M88085 M88086 M88087 M90814 M92287
GenPept AAA51927 AAA51929 AAA52137 AAH11616 AAM51826 BAG37810 BAG51884 CAG47042 CAI23491 EAX04071
RNA Seq Atlas 896

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca