Version 5.4
Homo sapiens Gene: TBCC
Summary
InnateDB Gene IDBG-87325.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBCC
Gene Name tubulin folding cofactor C
Synonyms CFC
Species Homo sapiens
Ensembl Gene ENSG00000124659
Encoded Proteins
IDBP-87327
tubulin folding cofactor C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:42744481-42746096
Strand Reverse strand
Band p21.1
Transcripts
ENST00000372876 ENSP00000361967
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0051087 chaperone binding
Biological Process
GO:0000902 cell morphogenesis
GO:0006184 GTP catabolic process
GO:0006457 protein folding
GO:0007023 post-chaperonin tubulin folding pathway
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0032391 photoreceptor connecting cilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036430
View Gene Order
ENSBTAG00000000940
Not yet available
Pathways
NETPATH
REACTOME
REACT_16967
Post-chaperonin tubulin folding pathway pathway
REACT_16952
Protein folding pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q15814
TrEMBL
UniProt Splice Variant
Entrez Gene 6903
UniGene Hs.619508 Hs.622228 Hs.75064
RefSeq NM_003192
HUGO HGNC:11580
OMIM 602971
CCDS CCDS4872
HPRD
IMGT
EMBL AK312681 AL353716 BC017479 BC020170 BT007002 U61234
GenPept AAB17539 AAH17479 AAH20170 AAP35648 BAG35561 CAI14818
RNA Seq Atlas 6903

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca