Version 5.4
Homo sapiens Gene: PTCRA
Summary
InnateDB Gene IDBG-87386.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTCRA
Gene Name pre T-cell antigen receptor alpha
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171611
Encoded Proteins
IDBP-87388
pre T-cell antigen receptor alpha
IDBP-379005
pre T-cell antigen receptor alpha
IDBP-379007
pre T-cell antigen receptor alpha
IDBP-810080
pre T-cell antigen receptor alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:42915989-42925835
Strand Forward strand
Band p21.1
Transcripts
ENST00000304672 ENSP00000304447
ENST00000446507 ENSP00000392288
ENST00000441198 ENSP00000409550
ENST00000616441 ENSP00000477815
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0070244 negative regulation of thymocyte apoptotic process
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036858
View Gene Order
ENSBTAG00000017097
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04330
Notch signaling pathway pathway
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001243168 NM_001243169 NM_001243170 NM_138296
HUGO
OMIM
CCDS CCDS4874 CCDS59019 CCDS59020 CCDS75457
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca