Version 5.4
Homo sapiens Gene: FGL1
Summary
InnateDB Gene IDBG-8817.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGL1
Gene Name fibrinogen-like 1
Synonyms HFREP1; HP-041; LFIRE-1; LFIRE1
Species Homo sapiens
Ensembl Gene ENSG00000104760
Encoded Proteins
IDBP-8821
fibrinogen-like 1
IDBP-8823
fibrinogen-like 1
IDBP-233949
fibrinogen-like 1
IDBP-233951
fibrinogen-like 1
IDBP-361732
fibrinogen-like 1
IDBP-476555
fibrinogen-like 1
IDBP-474758
fibrinogen-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:17864380-17910365
Strand Reverse strand
Band p22
Transcripts
ENST00000381841 ENSP00000371263
ENST00000381840 ENSP00000371262
ENST00000398056 ENSP00000381133
ENST00000398054 ENSP00000381131
ENST00000427924 ENSP00000401952
ENST00000522444 ENSP00000429757
ENST00000518650 ENSP00000428430
ENST00000522636
ENST00000523097
ENST00000518769
ENST00000519055
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0008203 cholesterol metabolic process
GO:0010906 regulation of glucose metabolic process
GO:0035634 response to stilbenoid
GO:0060612 adipose tissue development
Cellular Component
GO:0005577 fibrinogen complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031594
View Gene Order
ENSBTAG00000016177
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.491143 Hs.592967
RefSeq NM_004467 NM_147203 NM_201552 NM_201553 XM_005273450
HUGO
OMIM
CCDS CCDS6004
HPRD 09312
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca