Homo sapiens Gene: PER3
Summary
InnateDB Gene IDBG-88216.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PER3
Gene Name period homolog 3 (Drosophila)
Synonyms GIG13;
Species Homo sapiens
Ensembl Gene ENSG00000049246
Encoded Proteins
period homolog 3 (Drosophila)
period homolog 3 (Drosophila)
period homolog 3 (Drosophila)
period circadian clock 3
period circadian clock 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. [provided by RefSeq, Jul 2008]
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:7784320-7845177
Strand Forward strand
Band p36.23
Transcripts
ENST00000377541 ENSP00000366764
ENST00000377532 ENSP00000366755
ENST00000361923 ENSP00000355031
ENST00000473653
ENST00000463106
ENST00000494684
ENST00000602883
ENST00000613533 ENSP00000482093
ENST00000614998 ENSP00000479223
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0032922 circadian regulation of gene expression
GO:0045187 regulation of circadian sleep/wake cycle, sleep
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
Circadian rhythm pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL B4DR65
UniProt Splice Variant
Entrez Gene 8863
UniGene
RefSeq NM_001289861 NM_001289863 NM_001289862 NM_016831 XM_005263521 XM_005263522 XM_005263523 XM_005263527 XM_005263528 XM_005263529
HUGO HGNC:8847
OMIM 603427
CCDS CCDS72695 CCDS89
HPRD
IMGT
EMBL AK299123
GenPept BAG61177
RNA Seq Atlas 8863