InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ENO1

Summary

InnateDB Gene

IDBG-88402.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENO1

Gene Name

enolase 1, (alpha)

Synonyms

ENO1L1; MPB1; NNE; PPH

Species

Homo sapiens

Ensembl Gene

ENSG00000074800

Encoded Proteins

IDBP-88404

enolase 1, (alpha)

IDBP-721594

IDBP-722387

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:8861002-8879249

Strand

Reverse strand

Band

p36.23

Transcripts

ENST00000234590	ENSP00000234590
ENST00000464920
ENST00000497492	ENSP00000466406
ENST00000486051
ENST00000492343
ENST00000489867	ENSP00000468392

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.

Experimentally validated
Total	78 [view]
Protein-Protein	78 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0004634	phosphopyruvate hydratase activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006351	transcription, DNA-templated
GO:0009615	response to virus
GO:0030308	negative regulation of cell growth
GO:0044281	small molecule metabolic process
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0000015	phosphopyruvate hydratase complex
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031430	M band
GO:0070062	extracellular vesicular exosome