InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GSTO1

Summary

InnateDB Gene

IDBG-88848.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSTO1

Gene Name

glutathione S-transferase omega 1

Synonyms

GSTO 1-1; GSTTLp28; HEL-S-21; P28; SPG-R

Species

Homo sapiens

Ensembl Gene

ENSG00000148834

Encoded Proteins

IDBP-88850

glutathione S-transferase omega 1

IDBP-88852

glutathione S-transferase omega 1

IDBP-385153

glutathione S-transferase omega 1

IDBP-385154

glutathione S-transferase omega 1

IDBP-586749

glutathione S-transferase omega 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:104235356-104267459

Strand

Forward strand

Band

q25.1

Transcripts

ENST00000369713	ENSP00000358727
ENST00000369710	ENSP00000358724
ENST00000445155	ENSP00000406708
ENST00000432659	ENSP00000405325
ENST00000470554
ENST00000493946
ENST00000539281	ENSP00000441488

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	12 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0045174	glutathione dehydrogenase (ascorbate) activity
GO:0050610	methylarsonate reductase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014810	positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
GO:0019852	L-ascorbic acid metabolic process
GO:0042178	xenobiotic catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0071243	cellular response to arsenic-containing substance
GO:1901687	glutathione derivative biosynthetic process