Homo sapiens Gene: KIF1B
Summary
InnateDB Gene IDBG-88892.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIF1B
Gene Name kinesin family member 1B
Synonyms CMT2; CMT2A; CMT2A1; HMSNII; KLP; NBLST1;
Species Homo sapiens
Ensembl Gene ENSG00000054523
Encoded Proteins
kinesin family member 1B
kinesin family member 1B
kinesin family member 1B
kinesin family member 1B
kinesin family member 1B
kinesin family member 1B
kinesin family member 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:10210805-10381603
Strand Forward strand
Band p36.22
Transcripts
ENST00000263934 ENSP00000263934
ENST00000377093 ENSP00000366297
ENST00000377086 ENSP00000366290
ENST00000377083 ENSP00000366287
ENST00000377081 ENSP00000366284
ENST00000495136
ENST00000497835
ENST00000465635
ENST00000483340
ENST00000470616
ENST00000622724 ENSP00000480063
ENST00000620295 ENSP00000478500
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0016887 ATPase activity
GO:0019894 kinesin binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006915 apoptotic process
GO:0007018 microtubule-based movement
GO:0007270 neuron-neuron synaptic transmission
GO:0007274 neuromuscular synaptic transmission
GO:0008089 anterograde axon cargo transport
GO:0008152 metabolic process
GO:0030705 cytoskeleton-dependent intracellular transport
GO:0047497 mitochondrion transport along microtubule
Cellular Component
GO:0005739 mitochondrion
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_015074 NM_183416
HUGO
OMIM
CCDS CCDS111 CCDS112
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas