Version 5.4
Homo sapiens Gene: KIF1B
Summary
InnateDB Gene IDBG-88892.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIF1B
Gene Name kinesin family member 1B
Synonyms CMT2; CMT2A; CMT2A1; HMSNII; KLP; NBLST1
Species Homo sapiens
Ensembl Gene ENSG00000054523
Encoded Proteins
IDBP-88894
kinesin family member 1B
IDBP-88896
kinesin family member 1B
IDBP-88898
kinesin family member 1B
IDBP-88902
kinesin family member 1B
IDBP-88906
kinesin family member 1B
IDBP-810343
kinesin family member 1B
IDBP-810345
kinesin family member 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:10210805-10381603
Strand Forward strand
Band p36.22
Transcripts
ENST00000263934 ENSP00000263934
ENST00000377093 ENSP00000366297
ENST00000377086 ENSP00000366290
ENST00000377083 ENSP00000366287
ENST00000377081 ENSP00000366284
ENST00000495136
ENST00000497835
ENST00000465635
ENST00000483340
ENST00000470616
ENST00000622724 ENSP00000480063
ENST00000620295 ENSP00000478500
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0016887 ATPase activity
GO:0019894 kinesin binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006915 apoptotic process
GO:0007018 microtubule-based movement
GO:0007270 neuron-neuron synaptic transmission
GO:0007274 neuromuscular synaptic transmission
GO:0008089 anterograde axon cargo transport
GO:0008152 metabolic process
GO:0030705 cytoskeleton-dependent intracellular transport
GO:0047497 mitochondrion transport along microtubule
Cellular Component
GO:0005739 mitochondrion
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063077
View Gene Order
ENSBTAG00000004966
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.614041 Hs.619195 Hs.635990 Hs.713310 Hs.713387 Hs.734073
RefSeq NM_015074 NM_183416
HUGO
OMIM
CCDS CCDS111 CCDS112
HPRD 05818
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca