Homo sapiens Gene: ACSL5
Summary
InnateDB Gene IDBG-89780.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACSL5
Gene Name acyl-CoA synthetase long-chain family member 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197142
Encoded Proteins
acyl-CoA synthetase long-chain family member 5
acyl-CoA synthetase long-chain family member 5
acyl-CoA synthetase long-chain family member 5
acyl-CoA synthetase long-chain family member 5
acyl-CoA synthetase long-chain family member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:112374018-112428380
Strand Forward strand
Band q25.2
Transcripts
ENST00000354655 ENSP00000346680
ENST00000356116 ENSP00000348429
ENST00000354273 ENSP00000346223
ENST00000393081 ENSP00000376796
ENST00000433418 ENSP00000403647
ENST00000479936
ENST00000495539
ENST00000467340
ENST00000496328
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0008152 metabolic process
GO:0019432 triglyceride biosynthetic process
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:2001236 regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Fatty Acyl-CoA Biosynthesis pathway
Triglyceride Biosynthesis pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Synthesis of very long-chain fatty acyl-CoAs pathway
KEGG
Fatty acid biosynthesis pathway
Fatty acid degradation pathway
PPAR signaling pathway pathway
Peroxisome pathway
Adipocytokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.11638
RefSeq NM_016234 NM_203379 NM_203380
HUGO
OMIM
CCDS CCDS7572 CCDS7573
HPRD 16139
IMGT
EMBL
GenPept
RNA Seq Atlas