Version 5.4
Homo sapiens Gene: AHR
Summary
InnateDB Gene IDBG-8995.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AHR
Gene Name aryl hydrocarbon receptor
Synonyms bHLHe76
Species Homo sapiens
Ensembl Gene ENSG00000106546
Encoded Proteins
IDBP-8997
aryl hydrocarbon receptor
IDBP-597224
aryl hydrocarbon receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21683686
AHR deficiency imapirs TLR and NFkB-mediated proinflammatory gene expression after activation by a classical stimulus, such as LPS. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
PMID 21683686
[Mus musculus] Ahr deficiency impairs TLR and NFkB-mediated proinflammatory gene expression after activation by a classical stimulus, such as LPS.
PMID 23954130
[Mus musculus] Innate expression of Ahr plays a protective role in T-cell-induced colitis by suppressing T helper 17 cells, thus inhibiting proinflammatory cytokine production.
PMID 26857571
[Mus musculus] Uropathogenic Escherichia coli suppresses neutrophil migration early in bacterial cystitis by eliciting an Ido1-mediated increase in local production of kynurenines, which act through the Ahr to impair neutrophil chemotaxis.
Entrez Gene
Summary This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:17298622-17346152
Strand Forward strand
Band p21.1
Transcripts
ENST00000242057 ENSP00000242057
ENST00000463496 ENSP00000436466
ENST00000475440
ENST00000481944
ENST00000492120
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 62 [view]
Protein-Protein 56 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0035326 enhancer binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0051879 Hsp90 protein binding
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001568 blood vessel development
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006805 xenobiotic metabolic process
GO:0006915 apoptotic process
GO:0006950 response to stress
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0009410 response to xenobiotic stimulus
GO:0010468 regulation of gene expression
GO:0030522 intracellular receptor signaling pathway
GO:0030850 prostate gland development
GO:0030888 regulation of B cell proliferation
GO:0032922 circadian regulation of gene expression
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0048608 reproductive structure development
GO:0048732 gland development
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0034752 cytosolic aryl hydrocarbon receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019256
View Gene Order
ENSBTAG00000007746
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt P35869
TrEMBL A0A024R9Z8
UniProt Splice Variant
Entrez Gene 196
UniGene Hs.171189 Hs.713056
RefSeq NM_001621
HUGO HGNC:348
OMIM 600253
CCDS CCDS5366
HPRD 02596
IMGT
EMBL AC003075 BC069390 BC070080 CH236948 CH471073 D16354 D38044 L19872 U27656 U27657 U28060 U28061 U28062 U28063 U28064 U28065 U28066
GenPept AAA16210 AAA92082 AAA92083 AAA92084 AAH69390 AAH70080 BAA03857 BAA07235 EAL24281 EAW93686 EAW93687
RNA Seq Atlas 196

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca