Version 5.4
Homo sapiens Gene: RHAG
Summary
InnateDB Gene IDBG-90203.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHAG
Gene Name Rh-associated glycoprotein
Synonyms CD241; RH2; Rh50; RH50A; Rh50GP; SLC42A1
Species Homo sapiens
Ensembl Gene ENSG00000112077
Encoded Proteins
IDBP-90205
Rh-associated glycoprotein
IDBP-90207
Rh-associated glycoprotein
IDBP-806554
Rh-associated glycoprotein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is erythrocyte-specific and is thought to be part of a membrane channel that transports ammonium and carbon dioxide across the blood cell membrane. The encoded protein appears to interact with Rh blood group antigens and Rh30 polypeptides. Defects in this gene are a cause of regulator type Rh-null hemolytic anemia (RHN), or Rh-deficiency syndrome.[provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:49605158-49636839
Strand Reverse strand
Band p12.3
Transcripts
ENST00000371175 ENSP00000360217
ENST00000229810 ENSP00000229810
ENST00000618248 ENSP00000482984
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008519 ammonium transmembrane transporter activity
GO:0030506 ankyrin binding
Biological Process
GO:0006873 cellular ion homeostasis
GO:0015670 carbon dioxide transport
GO:0015696 ammonium transport
GO:0015701 bicarbonate transport
GO:0044281 small molecule metabolic process
GO:0048821 erythrocyte development
GO:0055085 transmembrane transport
GO:0060586 multicellular organismal iron ion homeostasis
GO:0072488 ammonium transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023926
View Gene Order
ENSBTAG00000011300
Not yet available
Pathways
NETPATH
REACTOME
REACT_20508
Rhesus glycoproteins mediate ammonium transport. pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_121380
Erythrocytes take up oxygen and release carbon dioxide pathway
REACT_121329
Erythrocytes take up carbon dioxide and release oxygen pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_120969
O2/CO2 exchange in erythrocytes pathway
REACT_111217
Metabolism pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q9UBB8 Q9UK69 Q9UL98
UniProt Splice Variant
Entrez Gene 6005
UniGene
RefSeq NM_000324
HUGO HGNC:10006
OMIM 180297
CCDS CCDS4927
HPRD
IMGT
EMBL AB036993 AF031550 AF031551 AF178842 AF178844
GenPept AAC04249 AAC04250 AAD56366 AAD56368 BAB00642
RNA Seq Atlas 6005

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca